The second government of Alfonso Fernández Mañueco was formed on 20 April 2022, following the latter's election as President of the Junta of Castile and León by the Cortes of Castile and León on 11 April and his scheduled swearing-in on 19 April, as a result of the People's Party (PP) and Vox being able to muster a majority of seats in the Cortes following the 2022 Castilian-Leonese regional election.

[1] It succeeded the first Mañueco government and has been the incumbent Junta of Castile and León since 20 April 2022, a total of 1,032 days, or 2 years, 9 months and 26 days.

Until 2024, the cabinet comprised members of the PP and Vox, as well as a number of independents proposed by both parties, to become the first PP–Vox coalition government to be formed as well as the first time a far-right party had entered a government either at the regional or national level in Spain since the country's transition to democracy.

[2][3][4] On 11 July 2024, Vox leader Santiago Abascal forced the break up of all PP–Vox governments at the regional level over a national controversy regarding the distribution of unaccompanied migrant minors among the autonomous communities.

[12] Alfonso Fernández Mañueco's first government was organised into several superior and governing units, whose number, powers and hierarchical structure varied depending on the ministerial department.