The second government of Fernando López Miras was formed on 1 August 2019, following the latter's election as President of the Region of Murcia by the Regional Assembly of Murcia on 26 July and his swearing-in on 29 July,[1][2] as a result of the People's Party (PP) allying itself with Citizens (Cs) and mustering the external support from Vox in exchange for policy compromises following the 2019 Murcian regional election.

[3] It succeeded the first López Miras government and has been the incumbent government of the Region of Murcia since 1 August 2019, a total of 2,025 days, or 5 years, 6 months and 14 days.

Until March 2021, the cabinet comprised members of the PP and Cs as well as a number of independents, to become the first coalition government to be formed in the region.

[4][5] From that point onwards, the government has been formed by the PP and a number of expelled members from both Cs and Vox.

López Miras's second government saw a number of cabinet changes during its tenure: The Council of Government is structured into the offices for the president of the Region of Murcia, the vice president and a number of ministries (10 from August 2019 to April 2021, 9 from April 2021 to May 2022 and 8 from May 2022).