[1] Viruses in this subfamily are distinguished by the absence of a turreted protein on the inner capsid to produce a smooth surface.

[2] Like other members of the Reoviridae family, viruses of the Sedoreovirinae subfamily are made of naked, icosahedral capsids containing 10-12 segments of linear double-stranded RNA (dsRNA).

The Baltimore System of viral classification categorizes Reoviridae in Group III.

There is not only the potential of a few of these viruses to cause human disease, but also to reduce the supply of crops and livestock.

Rotavirus A-E cause infantile gastroenteritis in humans and farm animals.