[7] Salifu began his youth career playing for Tamale Young Kotoko in the Ghana Juvenile Association Colts League.

He had a remarkable three-year spell at the club especially in 2012 and after his success in the games of the 2013 African U-20 Championship qualification, Salifu was highly sought after by top teams in Ghana including Asante Kotoko SC.

[8] After playing a key role for the Black Satellites at the FIFA U-20 Championship 2013 in Turkey he moved to the Tunisian side Club Africain.

[10] On 27 August 2016, Seidu Salifu agreed terms to play for Adana Demirspor in Turkey and managed just one league appearance.

Salifu was a member of the Ghana Under-20 national team that took part and in the 2013 FIFA U-20 tournament in Turkey.