[2] From there it crosses the vineyards of the Jura department, irrigating the communes of Nevy-sur-Seille, Voiteur, and Arlay, before reaching the agricultural plain of Bletterans.

It then passes Louhans and the Bresse area in the department of Saône-et-Loire, finally flowing into the Saône at La Truchère, a few kilometers south of Tournus.

The lower part, also prone to substantial flooding, is navigable for 39 kilometers from Louhans to La Truchère; there one can find catfish that have inhabited the river since the 1960s and that occasionally become very large.

The Seille catchment area covers 2300 km², containing some 600 km of watercourses in three departments: Jura, Saône-et-Loire, and Ain; it is thus located in three administrative regions.

A river contract for the Seille basin was put in place by the Saône and Doubs Mixed Syndicate in 2002, with financial assistance from regional and general councils, the Water Agency, and the State.