Seinäjoki is a significant crossing point, with connections toward Haapamäki, Helsinki, Vaasa and Oulu.

The Finnish Heritage Agency has classified Seinäjoki railway station as a nationally significant built cultural environment.

[1] In 1911, the railway line to Perälä was opened and was expanded to Kaskinen and Kristinestad the following year.

[1] The second station building designed by architect firm Heikki Castrén was built in 1968–1971.

[6] Seinäjoki is served by all trains from Helsinki towards Oulu and to Vaasa as well as by railbus services via Haapamäki to Jyväskylä (some terminate already at Ähtäri).