Seine River (French: Rivière-Seine) is a provincial electoral division in the Canadian province of Manitoba.

It was created by redistribution in 1989, and has formally existed since the 1990 provincial election.

Seine River is bordered to the south and east by the rural riding of Dawson Trail, to the north by Southdale and Riel, and to the west by St. Norbert.

Seine River's francophone population is 9%, and there is also a significant German community (4%).

Health and social services account for 14% of the riding's industry.