Sekani or Tse’khene are a First Nations people of the Athabaskan-speaking ethnolinguistic group in the Northern Interior of British Columbia.

The neighbours of the Sekani are the Babine to the west, Dakelh to the south, Dunneza (Beaver) to the east, and Kaska and Tahltan, to the north, all Athabaskan peoples.

Other forms occasionally found, especially in older sources, are Secunnie, Siccanie, Sikani, and the French Sékanais.

Although fish formed part of the diet, the Sekani relied more heavily on game, in contrast to their Carrier and Babine neighbors.

After cremation was discontinued, the Sekani revived an old custom, probably never entirely abandoned, of covering the dead man with the brush hut that had sheltered him during his last days and then deserting the locality for a period.