Semeno-Makarovo (Russian: Семено-Макарово; Bashkir: Семен-Макар, Semen-Makar) is a rural locality (a selo) in Yermekeyevsky Selsoviet, Yermekeyevsky District, Bashkortostan, Russia.

Semeno-Makarovo is located 12 km northeast of Yermekeyevo (the district's administrative centre) by road.

Vasilyevka is the nearest rural locality.

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