Established by the Florida Legislature in 1965 as Seminole Junior College, the school began operations in August 1966 with 700 students.

[5] The main campus is located in Sanford, adjacent to Lake Mary, and provides a variety of academic programs and includes the Grindle Honors Institute, a fine arts theater, planetarium, and the Center for Public Safety.

The Oviedo campus supports students aiming to transfer to the University of Central Florida through the DirectConnect program.

The Center for Economic Development in Heathrow focuses on workforce training and supporting local technology industries in collaboration with regional businesses.

Seminole State offers several online associate and baccalaureate degrees, as well as many certificate programs.