Semora is an unincorporated community in Caswell County, North Carolina, United States.

It lies just northwest of Hyco Lake and has some presence in Person County.

Semora is home to one of the oldest churches in North Carolina, the Red House Presbyterian Church.

[1] Neighboring North Carolina communities and municipalities include: Yanceyville, Milton, Roxboro, Leasburg, and Blanch.

In addition to the Red House Presbyterian Church, Wildwood is listed on the National Register of Historic Places.