[10] Because of his diminutive stature and weak appearance, Sena is bullied by his classmates in primary school; he is protected by Mamori Anezaki, his only friend.

[16] The Devil Bats spend their time playing several exhibition games and recruiting new members to the team, including wide receiver Taro "Monta" Raimon who becomes best friends with Sena.

The Devil Bats eventually lose a match against the visiting NASA Aliens from the United States but Sena befriends the team's ball boy turned running back Patrick "Panther" Spencer and the two promise to play each other again on the field.

For the team's summer training, Sena and the Devil Bats take a vacation to NASA's hometown of Houston, where they meet Hiruma's and Kurita's former mentor Doburoku Sakaki, who reluctantly allows Hiruma's request to put the team through a dangerous training regimen known as the "Death March"-which involves traveling on foot from Houston to Las Vegas through the Mojave Desert.

[17] During the Death March, Sena accidentally takes a detour to San Antonio where he meets Suzuna Taki and her brother Natsuhiko at the city's NFL's team's open tryouts.

The Taki siblings accompany the Devil Bats for the remainder of the Death March, with Natsuhiko becoming the team's tight end and Suzuna as the head of their cheerleading squad.

Deimon loses in the semifinals against Seibu but are given a chance to qualify for the Kantō tournament if they can win a consolation game against the Bando Spiders.

When Hiruma's throwing arm is injured by Rikiya Gao during the game against the Hakushu Dinosaurs, Sena briefly fills in as quarterback.

[21] For the Christmas Bowl, the Devil Bats face off against the undefeated Teikoku Alexanders, who are led by Takeru Yamato, the original Japanese Eyeshield 21.

[22] After winning the Christmas Bowl, Sena is asked by Japan's high school football committee to create a national team with Monta, Yamato and Taka Honjo.

[25] Some time later, Sena is chosen as one of two candidates from Japan for an open spot through the NFL's International Player Pathway Program, with the other being Hiruma.

In the game's final seconds, Sena manages to outrun every one of the Saikyodai Wizards' opposing players, securing a victory for the Enma Fires, however the winner of the IPPP's spot is never revealed.

He appears in both of the original video animations produced for the series: helping the Deimon Devil Bats to defeat the Uraharajuku Boarders in the Golden Bowl in the first OVA,[7] and surviving on a desert island (after Hiruma leaves him and his teammates to train) in the second.

Ain't It Cool News' Scott Green qualified Sena as "a rather likable put upon hero and visually interesting lead".