Senafe (Arabic: صنعفى, Tigrinya: ሰንዓፈ) is a market town in southern Eritrea, on the edge of the Eritrean highlands ሶይራ.

The soil is derived from volcanic ignimbrite,[1] and Senafe sits on the southeastern edge of a twenty kilometer wide caldera.

This map shows Sanafe at the edge of Tigray, connected to two routes, one leading west to Axum, the other south to Lake Ashangi.

Jerónimo Lobo, passed through Senafe in 1625, having entered the Horn of Africa by way of Beilul and having crossed the Danikil Desert.

[4] During his reconnaissance work for the 1868 British Expedition to Abyssinia (expedition against Emperor Tewodros II), Clements Markham visited Senafe, finding it situated "at the foot of the grand mass of sandstone rock about half a mile north-west of the camp, called Amba-Adana."