Seneca is a city in western Newton County, Missouri, United States.

Located on the southwestern border of the state, the city is part of the Joplin, Missouri Metropolitan Statistical Area.

[5] In the 1830s, many of the Seneca people still in the East had been pushed west of the Mississippi River into Indian Territory, which included parts of present-day Missouri, Kansas and Oklahoma.

"This tribe was moved to the Indian Territory not many miles west of town.

[7] The Early Show broadcast their national weather report from the city on the following Monday morning.

Seneca is located on Lost Creek, approximately one-quarter mile from the Missouri-Oklahoma state line.

[8] According to the United States Census Bureau, the city has a total area of 2.56 square miles (6.63 km2), all land.

US 60 joins the more famous U.S. Route 66, approximately 15 miles west of Seneca.

26.7% of all households were made up of individuals, and 14% had someone living alone who was 65 years of age or older.

27.7% of all households were made up of individuals, and 14.5% had someone living alone who was 65 years of age or older.