Depending on conditions, parts of the creek are navigable by light watercraft, such as kayaks or canoes.

Near Riley’s Lock there is a boat ramp into the creek which provides access to the Potomac River.

Long Draught Creek, a small tributary north of Gaithersburg has been dammed to form the 90 acres (0.36 km2) Clopper Lake which is the centerpiece of the park's day use area.

[2] During the 1920s and 1930s Seneca was a popular vacation spot for people from lower Montgomery County and Washington who came for the cooler temperatures, boating, swimming, and fishing.

There was a hotel near the canal and cottages lined the creek until they were washed away or destroyed by the several floods that have affected this area.