[5] Seneca Valley High School sits on land that was once the site of a dairy farm owned by baseball player Walter Perry Johnson.

In 1988, Seneca Valley changed to its present state of full-fledged high school with grades 9–12.

The larger facility also changed enrollment boundaries to draw more students from the Clarksburg and Northwest High School areas, and accommodates 14 career and technical education programs (CTE) for the upcounty student population.

[8] Seneca Valley primarily serves students living in Germantown and small populations in Clarksburg and Boyds.

Seneca Valley's biggest athletic rivalry is with the nearby Damascus High School.