On 27 February 1923, she was appointed teacher of children's education and vice principal at Kandilli Girls Junior High School.

On 27 October 1925, she returned to Istanbul Girls Teachers School as vice principal.

She served at the Istanbul Selçuk Hatun Vocational Girls School as a teacher for Turkish Literature from 15 October 1928, for Didactic, Physics and Chemistry from 1 September 1929, for Biology from 6 December 1930.

[2] In 1931, she established a private school "Yeni Türkiye" ("New Turkey") in Şişli, Istanbul, and served as its principal until she entered a politician's career.

[2] Seniha Hızal was nominated as a member of the parliament by the Republican People's Party (CHP).

On 13 June 1936, she attended the Congress of the Society for the Protection of Children, and was elected member of the Central Board of the institution.