However, the wedding was delayed because of the death of her elder sister Behice Sultan, sick with tuberculosis since childhood and to which Seniha had been very close, constantly writing her affectionate letters.

Seniha hadn't been on good terms with Abdul Hamid for unknown reasons,[11] and so in 1878, she and her husband, and her siblings including her brothers Prince Ahmed Kemaleddin, and Prince Selim Suleiman, and sister Princess Fatma, were all involved in the Ali Suavi incident with the objective of restoring Murad to the throne.

[12] In October 1898,[13] she met with the German Empress Augusta Victoria in the harem of the Yıldız Palace, when the latter visited Istanbul for a second time with her husband Emperor Wilhelm [14] In her memoir, Ayşe Sultan, daughter of Abdülhamid II, remembered: "Familiar as he was with his sisters' (Seniha Sultan and Mediha Sultan) habit of chattering away rapidly and guffawing, Abdülhamid II had counseled and beseeched them to behave in a dignified fashion, but nonetheless the sisters fell back on their old habits.

Baba ("dad", the Sultan Abdülhamid II) felt compelled to tell the Empress, "Please forgive my sisters, they're a bit nervous."".

Seniha Sultan's husband was very critical of her brother Abdul Hamid's governance, never missing an occasion to speak out.

[15] At the exile of the imperial family in March 1924, Seniha was the oldest living Ottoman princess, age seventy-three.

After Mehmed's death, she didn't have enough money on her own to rent a house, and so slept in the public gardens of Cimiez, Nice.

[16] Seniha Sultan died at the Villa Carabacel on 15 September 1931 at age seventy-nine in Nice, France the last surviving child of Abdulmejid,[17] and was buried in the cemetery of the Sulaymaniyya Takiyya in Damascus.

[21] She used to wear dresses of the most superb cloth, with her tiara on her head on formal occasions, and she also wore gowns with long trains in the European fashion spreading out behind her.