Nandi kaBhebhe eLangeni (Nandi, daughter of Bhebhe, from eLangeni district), bore him his first son Shaka, said to have been conceived during an act of ukuhlobonga, a form of coitus interruptus without penetration allowed to unmarried couples at a time known as "the fun of the roads" (amahlaya endlela), but the lovers became carried away.
Senzangakhona was unwilling to acknowledge Nandi as his chief consort, an important status symbol among the AmaZulu.
Senzangakhona' sixth wife, Mpikase kaMlilela Ngobese, bore Dingane, who took over the Zulu kingdom after assassinating his half-brother Shaka in 1828 at present-day Stanger.
Senzangakhona's ninth wife, Songiya kaNgotsha Hlabisa, bore Mpande, who became king when he overthrew Dingane in 1840.
Mpande’s son, Cetshwayo kaMpande, was in some aspects the last great king of the Zulus before the British Empire invaded their territory.