Septème (French pronunciation: [sɛptɛm]; Arpitan: Septèmo) is a commune in the Isère department in southeastern France.

[3] The name of Septème reflects its location: at the seventh milepost on the Roman road between Vienne and Milan.

A Roman camp had been established here, on a hill overlooking the valley.

During the second half of the 12th century, the site was encircled by a strong enceinte one kilometre in length with three gates.

After the unification of Septème to Dauphiné, a more modern castle was constructed in the 14th and 15th centuries.