[2] The band recorded their first full-length album, Mystic Places of Dawn, in April 1994 at the Storm studio with the co-production of Magus Wampyr Daoloth (who had been the keyboardist for Rotting Christ).

[4] The group split up in October 2003, and after the breakup, its members moved on to different or existing projects: Christos Antoniou continued involvement with Chaostar, which he formed in 1998, and Katsionis played guitar for Nightfall and keyboards for Firewind.

On February 19, 2007, Septic Flesh announced a reunion for Greece's Metal Healing Festival featuring Orphaned Land, Rage and Aborted, set to take place July 20–22.

[11][12][13][14][15] In early June 2017, band members claimed that Septicflesh's tenth album, titled Codex Omega, is officially due to release on September 1, 2017.

The show was recorded and was released through Season of Mist in July 2020 as the band's first official live album, titled Infernus Sinfonica MMXIX, in audio and video format.

[19] In September 2024, Septicflesh were the first metal band to perform in Odeon of Herodes Atticus, once again featuring a full orchestra and a choir.