Serafino Cretoni (4 September 1833 – 3 February 1909) was an Italian Cardinal of the Roman Catholic Church who served as Prefect of the Sacred Congregation of Rites from 1903 until his death, and was elevated to the cardinalate in 1896.

Serafino Cretoni was born in Soriano, and studied at the Pontifical Roman Athenaeum S. Apollinare, where he obtained his doctorate in theology.

Ordained to the priesthood in 1857, Cretoni then taught philosophy at the Pontifical Urban Athenaeum of Propaganda Fide in Rome.

On 16 January 1893 Simeoni was appointed Titular Archbishop of Damascus by Pope Leo XIII, receiving his episcopal consecration on the following 5 February from Cardinal Raffaele Monaco La Valletta.

Simeoni was named Nuncio to Spain on 9 May that year, and created Cardinal Priest of Santa Maria sopra Minerva by Pope Leo in the consistory of 22 June 1896.