Derivative names in other languages are - Polish: Sereje, German: Serrey, English sometimes "Serey"[2] The lands were inhabited by the Lithuanian tribe Dainavians.

Due to the frequent raids and pillaging of the Teutonic Order, the Dainavians moved to other parts of Lithuania abandoning the lands and Seirijai became a wilderness.

After the defeat of the Teutonic Order in the Battle of Grunwald and the Treaty of Melno (1422), the land became populated again and started to grow economically.

King of Poland and Grand Duke of Lithuania Sigismund I the Old donated Seirijai to Jerzy Radziwiłł, and later it became a possession of Radziwill family.

On September 11, 1941, 953 Jews from Seirijai were murdered in the Baraučiškės Forest, including 229 men, 384 women and 340 children.