Hall of Fame trainer D. Wayne Lukas bought her at the 1993 Keeneland July yearling sale for $150,000 for Eclipse of Merit owners Robert and Beverly Lewis.
One of her top performances was in the second jewel of the Fillies Triple Crown, the $200,000 Grade 2 Black-Eyed Susan Stakes.
Serena's Song beat a field of seven stakes winners, including Conquistadoress and Rare Opportunity.
Serena's Song raced 15 times as a four-year-old and won 5, never coming worse than third, while running at eight different tracks.
She also came very close to winning the Whitney Handicap over males, and was second in the Breeders' Cup Distaff to bring her year's earnings to $1,164,133.