Serena is an unincorporated community and census-designated place in LaSalle County, Illinois, United States.

[2] Serena was the residence of Peg McDonnell Breslin, the first woman elected to the Illinois Appellate Court outside Cook County.

According to the 2021 census gazetteer files, Serena has a total area of 0.25 square miles (0.65 km2), all land.

[5] As of the 2020 census[6] there were 129 people, 4 households, and 4 families residing in the CDP.

This LaSalle County, Illinois location article is a stub.