Serena Ortolani (born 7 January 1987 in Ravenna) is an Italian volleyball player.

In the 2005/06 season, she won her first Coppa Italia and Scudetto with Foppapedretti Bergamo.

In 2006, she was selected again for the national team for the 2006 FIVB Women's World Championship, held in Japan, where she helped Italy win fourth place.

In 2007, she helped the Italian volleyball team win the Women's European Volleyball Championship, held in Belgium and Luxembourg and repeated this success a few months later at the World Cup in Japan, thereby helping Italy gain qualification for the 2008 Olympic Games in Beijing, where she subsequently competed.

She won the 2008–09 CEV Indesit Champions League playing with Volley Bergamo and was awarded "Most Valuable Player".