Gakpé began his career playing for his local club UMS Pontault-Combault, whom AS Monaco share a partnership with.

Serge then signed his first professional contract on 4 January 2007, inking a three-year deal with the club.

At the end of January 2012, it was announced that Gakpé had signed for Belgian club Standard Liège on a season-long loan.

[5] Even though Gakpé holds French nationality and represented France at youth level, he chose to play for the Togo national team, and was called up for the 2010 FIFA World Cup qualification match against Morocco on 6 September 2009.

[6] In 2013 he played in all matches at 2013 Africa Cup of Nations when his team reached the quarter-finals.