His father was Vitali Bezrukov, an actor and director who worked at the Moscow Satire Theatre.

Sergei's mother was Natalia Bezrukova (née Surova), she graduated from the Gorky College of Soviet Trade and worked as a shop manager.

He voiced twelve characters on the show, among them such famous personalities as Boris Yeltsin and Vladimir Zhirinovsky.

[9] In 2002 Bezrukov gained his big break; he got the role of gang leader Sasha Belov in the popular crime TV show Brigada.

[12] In 2020, he advocated the 2020 amendments to the Constitution of Russia, which, in particular, are defining marriage as a relationship between one man and one woman.

[19] At the end of 2013, the media, citing Bezrukov's father, reported that Sergei has young children: daughter Alexandra and son Ivan; their mother was identified as a St. Petersburg actress by the name of Kristina Smirnova (born 1983 in Latvia).