He is best known for his roles in the award-winning movies Simple Things (2006) and How I Ended This Summer (2010), both directed by Alexei Popogrebski.

[1] Sergei Puskepalis was born in 1966 to a Lithuanian father and a Bulgarian mother from Transnistria, in Kursk, then Soviet Union.

After graduating from the Moscow GITIS, he staged the play "Twenty-Seven" Alexey Slapovsky and this performance was one of the festival Baltic House.

From June 2009 to February 2010 - chief director of the Russian State Academic Drama Theater named after Fyodor Volkov in city of Yaroslavl.

Later Popogrebski invited Sergei Puskepalis to star roles in the films Simple Things and How I Ended This Summer.