Elected to the State Duma as a member of the Democratic Party of Russia in 1993, he first associated with his then-friend, and later bitter rival, Dmitry Rogozin.

Other prominent candidates included Dmitry Rogozin, Chairman of the Duman Foreign Affairs Committee and co-chairman (with Glazyev) of Rodina, and also former Central Bank head Viktor Gerashchenko.

In 2004, both Glazyev and Gerashchenko sought the presidency on separate tickets, with Rodina's leaders voting to remain neutral in the contest.

During the election, Glazyev portrayed himself as a champion of social justice and an opponent of political corruption, particularly in the form of the Russian oligarchs.

He pledged to write a guarantee of a high standard of living into the constitution, provide universal health care and free public education, triple the minimum wage, protect the rights of trade unions, redistribute the wealth belonging to the oligarchs, and increase economic growth.

He also promised to eradicate the notorious Russian Mafia, purge corrupt bureaucrats and police, and protect the country from terrorism.

[2] In July 2012, Putin appointed Glazyev as presidential aide for the coordination of the work of federal agencies in developing the Customs Union of Belarus, Kazakhstan, and Russia.

One of his books has been published in English translation by the LaRouche movement's Executive Intelligence Review as Genocide: Russia and the New World Order (ISBN 0-943235-16-2).

[5] On March 17, 2014, a day after the Crimean status referendum, Glazyev was one of the first seven persons who were placed under executive sanctions by President Obama.

[6] However, according to Glazyev, he has not been negatively affected by these sanctions because he has neither property nor accounts of any sort in the United States, nor had he any plans to come to America.

move to a scientifically grounded strategy for economic growth, improvement of the people's welfare, and restoration of the spiritual-intellectual strength and the scientific and technical potential of the Russian State.In an interview with the National Interest,[7] Glazyev said: The entire crisis in Ukraine was orchestrated, provoked, and financed by American institutions in cooperation with their European partners.

This work led to the sad situation that now in Ukraine neo-Nazi and neo-fascists ideas prevail, as does admiration for, more than anything, Stepan Bandera's associates who in their time murdered Jews, Ukrainians, Russians, Poles, and whomever they wanted, burning or otherwise killing them under Nazi leadership.In August 2013 Glazyev said that stating that all Ukrainians favor Ukraine to integrate in the European Union "is some kind of sick self-delusion"[9] and, citing a December 2012 poll,[10] said "surveys by Ukrainian sociological services say something different: 35% of people prefer the European Union and 40% the Customs Union".

[9] He blamed "numerous political scientists and experts, who have fed on European and American grants for 20 years, and a whole generation of diplomats and bureaucrats who have appeared after the years of the 'orange' hysteria, who are carrying out an anti-Russian agenda" and "who are too far from the economy and real life, don't really know their country's history and are divorced from its spiritual traditions" for creating "an effect that Ukraine doesn't want".

When the Custom Union wasn't mentioned the support reached 50%, with even greater numbers in a poll by German state-owned broadcaster Deutsche Welle, in which people aged 18-65 were interviewed in cities with more than 50,000 inhabitants.

[18][19] Specially trained people should knock out “Banderovtsy” (Neo-Nazis) from the building council, and then they should arrange the meeting of the regional state administration, gather executive authorities.

And for this it must be provided, as it was done in Kharkiv – in Kharkiv people came into [the regional administration] threw all “Banderovtsy” out, found the ammunition depot, now engage its disposal and will gather Regional State Administration and will also appeal to our President.In the intercepts Glazyev makes it clear that the riots and protests must look as if they were grassroots and inspired by local residents in spite of the fact that large part of funding for the pro-Russian militants came from Russia.

Sergey Glazyev: Then you have to make a cost estimate, I will give it to those, let them work on the estimate.In a 2016 (member of the State Duma) Konstantin Zatulin gave an interview for Russian Radio Business FM in which he confirmed that the calls indeed took place, only noting that the recordings were "taken out of context".

[22] Following the August 2017 round of sanctions against the Russian Federation by the American Congress, Glazyev suggested that the USA should be officially designated as an "aggressor country."

[31] Analysts believed that Glazyev held greater potential than Gennady Zyuganov in appealing to moderate left Russians.

[27] Glazyev had hoped that he could perform well enough in the election to cement a perception of him as the rising political star of the Russian far-left.

After the Supreme Court upheld the disqualification of Gerashchenko, the spurned Rogozin personally endorsed Putin rather than supporting Glazyev.