At the professional club level, he plays for Fakel Novy Urengoy.

Sergey Grankin captained the Youth team of Russia at the victorious European Championship in 2004 in Croatia, and the 2005 World Championships in India, where he first confidently made himself known.

Mostly due to the mood of their captain, the Russians won the final match over Brazil in the first set when the score was 23:16 in favor of their rivals, the Russian scored 7 points in a row with Grankin serving , pulled out a losing set and broke down the Brazilians who lost the following two sets.

He married his fiance Bruna de Araujo on 19 August 2012.

At the 2013 European Volleyball Championship - where Russia won the gold medal and was awarded as the best setter of the tournament.