Sergio Santarini (Italian pronunciation: [ˈsɛrdʒo santaˈriːni]; born 10 September 1947) is a retired Italian professional football player and coach who played as a defender.

Throughout his career, Santarini played for Rimini, Internazionale, Roma, and Catanzaro, winning three Coppa Italia titles during his 13 years with Roma.

At international level, Santarini represented the Italy national football team on two occasions between 1971 and 1974, scoring once.

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