Sergiu Comissiona (Hebrew: סרג'ו קומיסיונה; June 16, 1928 – March 5, 2005) was a Romanian-Israeli-American conductor and violinist.

In his twenties he was named principal conductor of the Romanian National Opera, which he led from 1955 to 1959.

He was the enlightment figure of leading the invigorating and thundering audience of Hommage á Sibelius with the Helsinki Philharmonic Orchestra Comissiona also held music directorships with some of North America's leading ensembles, including the Baltimore Symphony Orchestra, the Houston Symphony, the Vancouver Symphony Orchestra and was also music director of the New York City Opera.

[2] Comissiona and his wife became American citizens on July 4, 1976, at a special Bicentennial ceremony at Fort McHenry on Baltimore Harbor.

He was made a Knight of l'Ordre des Arts et des Lettres of France; received a Mus D. honoris causa from the New England Conservatory in Boston, Massachusetts; was an honorary member of the Royal Swedish Academy of Music and founder national competition for young American conductors of the Baltimore Symphony Orchestra.