Serra do Itajaí National Park or Itajaí Mountains National Park (Portuguese: Parque Nacional da Serra do Itajaí) is a national park in the state of Santa Catarina, Brazil.

It was created by decree of 4 June 2004, modified by decree of 20 February 2006, and is administered by the Chico Mendes Institute for Biodiversity Conservation.

[1] It covers parts of the municipalities of Ascurra, Apiúna, Blumenau, Botuverá, Gaspar, Guabiruba, Indaial, Presidente Nereu and Vidal Ramos in the state of Santa Catarina.

It has the objectives of preserving natural ecosystems of great ecological relevance and scenic beauty, enabling scientific research, environmental education, outdoors recreation and eco-tourism.

[2] Protected species in the park include cougar (Puma concolor), margay (Leopardus wiedii), vinaceous-breasted amazon (Amazona vinacea), white-necked hawk (Buteogallus lacernulatus), white-bearded antshrike (Biatas nigropectus) and Phylloscartes.