The Serranía del Perijá, Cordillera de Perijá or Sierra de Perijá [pe.ɾi.ˈxa] is a mountain range, an extension of the eastern Andean branch (Cordillera Oriental), in northern South America, between Colombia and Venezuela, ending further north in the Guajira Desert, a total distance of about 310 kilometres (190 mi).

Starting at the southernmost point, near Ocaña, Colombia, this mountain range forms the boundary between the Colombian departments of Norte de Santander and Cesar, and then as the range progresses north, it forms the international boundary between Venezuela (Zulia State) and Colombia (Cesar Department).

Venezuela has set aside a substantial part of the central part of the range as a national park (Sierra de Perijá National Park), and Colombia has a smaller one.

The town of Cojoro was the first one completed, followed by communities for the Wayuu and Goajira peoples.

The climate is mostly tropical humid forests, with cultivation of coffee and papaver flowers.