The waters of the Serrano River eventually reach Seno Ultima Esperanza.

The Chilean scientific agency CEQUA confirmed an infestation of the algae Didymo in the Serrano River in early 2015.

Notably not far from the southern area of the river's mouth is situated the Cueva del Milodon, a cave where evidence of prehistoric man's habitation has been found, illustrating arrival of humans approximately 6,000 BC.

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