Serre-lès-Puisieux is a village in the commune of Puisieux in the Pas-de-Calais department in Hauts-de-France in northern France.

Colincamps lies to the west, Hébuterne to the northwest, Puisieux to the northeast and Beaumont-Hamel to the south.

During the first two and a half years of the First World War, Serre-lès-Puisieux was held by the Germans and marked the northern point of the allied attack on the first day of the Battle of the Somme.

[1] The front line near the village remained more or less unchanged up until the end of the battle in November 1916.

[1] The Allies retook the village on 14 August 1918, during the Hundred Days Offensive.