Sespe Creek (Chumash: S'eqp'e', "Kneecap"[4]) is a stream, some 61 miles (98 km) long,[5] in Ventura County, southern California, in the Western United States.

Sespe Creek receives most of its rainfall between January and April, and furnishes 40% of the water flowing in the Santa Clara River.

The confluence of Sespe Creek with the Santa Clara River provides an important connection to upland systems and potential migration corridor for four endangered species: southwestern willow flycatcher (Empidonax traillii extimus), least Bell's vireo (Vireo bellii pusillus), arroyo toad (Bufo microscaphus californicus), and California red-legged frog (Rana aurora draytonii).

[16] The authenticity of the Sespe Creek specimen is supported by reports of beaver historically in the Santa Clara River until Europeans arrived, according to oral Ventureño Chumash history taken by ethnolinguist John Peabody Harrington in the early twentieth century.

[17]Also there is a Chumash pictograph of a beaver at Painted Rock in the Cuyama River watershed due west of Mt.

[18] Additionally, the Hearst Museum in Berkeley has a Ventureño Chumash shaman's rain making kit made from the skin of a beaver tail and a tobacco sack.

The Chumash would treat the stick with 'ayip ( a ritually powerful substance made from alum) and then plant it in the ground to create a permanent spring of water".

[21] Finally, the Chumash word for beaver is Chipik, spelled "č'ǝpǝk'" in Barbareño and "tšǝ'pǝk" (Timothy Henry personal communication 2011-01-23), and "č'ɨpɨk" in Ineseño (Samala).

Andy Bisaccia recalls taking Boy Scouts camping there between 1938 and 1944 and remembers seeing beaver, their dams, and lodges, and that they could be observed off of Highway 33 in that vicinity.