Setepenre or Sotepenre (Ancient Egyptian: stp-n-rꜥ "chosen of Re")[1] was an ancient Egyptian princess of the 18th Dynasty; sixth and last daughter of Pharaoh Akhenaten and his chief queen Nefertiti.

[2] Setepenre was born around the 9th[3] to 11th year of her father Akhenaten in the city of Akhetaten.

[4] She had five older sisters named Meritaten, Meketaten, Ankhesenpaaten, Neferneferuaten Tasherit, and Neferneferure.

[5] One of the earliest depictions of Setepenre is in a fresco from the King's House in Amarna.

[3][4] The next time the six princesses appeared together was in Year 12, on the eighth day of the second month of winter, during the so-called "reception of foreign tributes".

In the tomb of Meryre II, Akhenaten and Nefertiti are shown seated in a kiosk, receiving tribute from foreign lands.