He is the creator and host of The Thinking Atheist online community, podcast, and YouTube channel, as well as the author of four self-published books.

He later commented, "As I spoke words of comfort to our listeners and callers, I struggled to reconcile the notion that the God of Matthew 10, the one who considered us worth 'more than many sparrows,' would design or abide the taking of Mullins' earthly life in such a pointless, gruesome manner.

"[5] The terrorist attacks of September 11, 2001, also played a role in strengthening Andrews' doubts about religion and leading him to apostasy.

[5][6] In an interview with Rob Palmer for the Center for Inquiry, Seth stated, "After an arduous year, I realized that I had been living an inherited belief system and that the Bible is unsustainable scientifically, historically, and morally.

"[7] In 2004, Andrews watched a video of atheist Christopher Hitchens debating Rabbi Shmuley Boteach, which made him decide to leave his faith.

[9] He created a website and Facebook page, both called The Thinking Atheist,[10] to connect with other non-believers online and "share some of the information that I had found helpful in the hope of making the journey out of superstition (religion) easier for others".

[12] In addition, he has a YouTube channel called The Thinking Atheist which hosts numerous self-produced atheist-related videos where he attempts to debunk the claims of Christians.

"[15] An Oklahoma news website asked Andrews about his opinion on Madalyn Murray O'Hair, the founder of American Atheists, who sued to end compulsory Bible reading in public schools in the 1960s.

"[12] In an interview with the Center for Inquiry, when asked about coming out against your support group's belief, he replied, "Well, it’s tribal reinforcement.

[16][17] Paleontologist Donald Prothero commented on the book as follows: Andrews writes in a friendly, relaxed folksy style, just as you hear him on the air, and it suits his humble narrative well.

He is a good storyteller and conversationalist not only in his radio work, but on the printed page as well... Andrews' book is a short but very enjoyable read.