Grahame-Smith is also the co-creator, head writer and executive producer of The Hard Times of RJ Berger, a scripted television comedy appearing on MTV.

Grahame-Smith was born in Rockville Centre, New York, the son of Deborah Ann (née Williams) and Barry Michael Greenberg.

Enamored of the idea, Grahame-Smith immediately began working on the novel, first by reading Pride and Prejudice and then by inserting the gruesome zombie elements, a process he has described as similar to microsurgery.

Building on the success of Pride and Prejudice and Zombies, Grahame-Smith wrote another mash-up, Abraham Lincoln, Vampire Hunter.

As the title suggests, this book traces Abraham Lincoln's life from childhood through assassination, relying upon his "secret diaries" to reveal his central role in a worldwide struggle against vampirism.

"[8] In addition to writing novels, Grahame-Smith made his debut as a comic book writer on Marvel Zombies Return: Hulk with artist Richard Elson.

Grahame-Smith adapted his book, Abraham Lincoln: Vampire Hunter,[12] for the screen, for producers Tim Burton and Timur Bekmambetov.

[13] In 2011, Pride and Prejudice and Zombies was optioned by Lionsgate Entertainment, with Natalie Portman producing, and David O. Russell initially set to adapt and direct.

[26] While working on Clark and Michael, Grahame-Smith met another producer on the series, David Katzenberg (son of Jeffrey), who would become his partner in KatzSmith Productions.

Under the KatzSmith banner, Grahame-Smith and Katzenberg created, wrote, and produced a scripted comedy for MTV called The Hard Times of RJ Berger, which follows an awkward high-school loser who gains notoriety for his extraordinary endowment.