Sethurama Iyer CBI is a 2004 Indian Malayalam-language mystery crime film directed by K. Madhu and written by S. N. Swamy.

[1] The base story and initial scenes are adopted from Arthur Hailey's novel Detective.

[2] The movie begins with Sethurama Iyer visiting Isow Alex, a convicted serial killer who is awaiting his execution.

Alex, who had been living a wild life then, had committed the crime high on narcotic drugs.

The murder case was left to the CBI for investigation and an able officer, Balagopal, nabbed Alex in no time.