[1] The Seti originates from the snow fields and glaciers around the twin peaks of Api and Nampa in the south-facing slopes of the main Himalayas.

The area is near the trijunction of the borders of Nepal, India (Kumaon, Uttarakhand), and China (Tibet).

The river first flows in a south-easterly direction, then turns and flows in a south-westerly and finally south-easterly again before joining the Karnali or Ghaghara River.

It has cut a spectacular gorge across the Mahabharat Range and appears to be lost amongst caves and tunnels for a short distance.

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