[2] It is named for Elizabeth Ann Seton (1774–1821), who founded the Sisters of Charity and who, after her death, was canonized as the United States' first native-born saint.

[4] During the 1980s, men were regularly admitted to many programs at Seton Hill College, including music and theater.

[5] Seton Hill University received widespread public attention[6][7][8] after announcing a technology plan that includes providing an iPad to all full-time students, as well a 13" MacBook to all incoming freshmen.

Subjects include art, writing, education, therapy, business, orthodontics, and physician assistant studies.

During the 2006–07 school year, Seton Hill had dual membership with both the NAIA and the NCAA as part of the transition.

Seton Hill competes in 19 intercollegiate varsity sports: Men's sports include baseball, basketball, cross country, football, lacrosse, soccer, track & field and wrestling; while women's sports include basketball, cross country, equestrian, field hockey, golf, lacrosse, soccer, softball, tennis, track & field and volleyball.

[15] In 2006, the baseball team received a berth to the NAIA World Series in the program's third year of existence.

In 2014, the baseball team had its most successful season; winning the PSAC, the Atlantic Regional, and advancing to the College World Series.