Most of Settsu's area comprises the modern day cities of Osaka and Kōbe.
During the Sengoku period, the Miyoshi clan ruled Settsu and its neighbors, Izumi and Kawachi, until they were conquered by Oda Nobunaga.
The regents of Hideyoshi's son soon quarreled, and when Ishida Mitsunari lost the Battle of Sekigahara, the area was given to relatives of Tokugawa Ieyasu.
[2] During the Sengoku period Settsu became the main exporting centre of matchlock firearms to the rest of Japan.
The Kohama style (小浜流, Kohama-ryū) of sake brewing was practiced at the Kohama-juku (小浜宿) in the Amagasaki Domain of Settsu Province during the Edo period.