[1] On 15 July 2014, Regent celebrated the steel cutting of the new ship at Fincantieri's yard in Sestri Ponente, near Genoa.

[3] On 30 October 2015, Seven Seas Explorer floated out from the dry dock at the shipyard following completion of her exterior outfitting.

[12] Seven Seas Explorer set sail on her 14-night maiden voyage on 20 July 2016 from Monte Carlo to Venice.

[13][5] The ship spent her inaugural season sailing in the Mediterranean, before re-positioning to Miami for cruises in the Caribbean.

[13][14] Since then, Seven Seas Explorer has also visited ports in Northern Europe, Africa, and South America.

[16][17] In the latter half of 2020, she was to debut in Asia, and sail her maiden Alaska season in the summer of 2021,[17] however, these voyages were disrupted by the Covid-19 pandemic and the subsequent suspension of cruises embarking through September 2021.