In Chapter IX of MacKinlay Kantor's Pulitzer Prize-winning novel "Andersonville" (1955), the father of one of the main characters is commissioned as a lieutenant in Company G of the Seventh Iowa Cavalry.

In 1864, three companies of the regiments were part of Lieutenant Colonel Samuel M. Pollock's 1st Brigade of Brigadier General Alfred Sully's District of Iowa.

Units of the regiment were at Camp Rankin on the South Platte in January, 1865 when more than 1,000 plains Indians attacked the fort and stage station at Julesburg during the Sioux Wars following the Sand Creek Massacre.

In the Battle of Julesburg, 14 men of the 7th were killed, including 4 non-commissioned officers.

[1] Company F of the regiment accompanied Colonel James H. Kidd's column of the Powder River Expedition in 1865 to the Powder and Tongue river valley's in Dakota Territory and Montana Territory.