Sewickley is a borough in Allegheny County, Pennsylvania, United States, 12 miles (19 km) west northwest of Pittsburgh along the Ohio River.

Historian Charles A. Hanna suggested "Sewickley" came from Creek words for "raccoon" (sawi) and "town" (ukli).

[4] According to Hanna, the Asswikale branch of the Shawnee probably borrowed their name from the neighboring Sawokli Muscogee before the former's migration from present-day South Carolina to Pennsylvania.

"[8] The valley surrounding the Big Sewickley Creek was surveyed in 1785 and sold to American Revolutionary War veterans.

After the Battle of Fallen Timbers in 1794, settlers began to trickle in to the area, with flatboats, keelboats, and steamboats forming an industry along the Ohio River.

[9] The borough was incorporated as simply Sewickley on July 6, 1853, after growth continued as the Pittsburgh, Fort Wayne and Chicago Railway was built through the area.

Most of these municipalities – not including Leetsdale and parts of Leet Township – share the Sewickley post office and its 15143 zip code.

Heritage Valley Sewickley provides comprehensive health care for residents of Allegheny, Beaver, Butler and Lawrence counties in Pennsylvania; eastern Ohio and the panhandle of West Virginia.

Heritage Valley offers medical, surgical and diagnostic services at its hospitals, community satellite facilities and in physician offices.

The Bruegger's Bagels on Beaver Street was temporarily transformed into an operating McDonald's during shooting of Houseguest.

[33] The fictional 1/24 scale town of Elgin Park, by artist and photographer Michael Paul Smith, was loosely based on Sewickley.

[34][35] Sid Lang, a primary character in Wallace Stegner's 1987 novel Crossing to Safety, grew up in Sewickley.