Seymour is a census-designated place (CDP) and unincorporated community in Blount and Sevier counties in the U.S. state of Tennessee.

The first court of Sevier County, State of Franklin, was held at Newell's Station in March 1785.

[6] During the 19th century, the community was known as Trundles Crossroads where the main road from Sevierville forked, with one branch continuing northward to Knoxville and one branch westward to Maryville (now the intersection of Boyds Creek Highway and Old Sevierville Pike).

[8] The Trundles Crossroads Post Office changed its name soon afterwards to reflect the community's designation.

[9] On multiple occasions, residents have met to discuss the possibility of incorporating as a town or city.

The community is situated in a rolling valley where the foothills of the Great Smoky Mountains give way to the Ridge-and-Valley Appalachians.

[12] Chapman Highway (part of U.S. Route 441) traverses Seymour, connecting the community with Knoxville to the northwest.

Near the center of Seymour, Chapman Highway forms a four-way intersection with U.S. Route 411, which approaches from Maryville to the west, and Boyds Creek Highway (State Route 338), which approaches from Boyds Creek to the east.