[3] He attended Agazi Secondary School in Adigrat and Bahir Dar Polytechnic Institute from which he received a diploma in industrial chemistry in 1971.

[5] Seyoum served as chairman of the Foreign Affairs Committee of the Ethiopian People's Revolutionary Democratic Front (EPRDF) in the 1980s.

[10] On 28 December 2004, Mesfin made a speech to the UN General Assembly in New York on the policy in the region, in particular the relationship of Ethiopia to Eritrea and Somalia.

[14] He visited Singapore in December 2012 to potentially set up an Ethio-Singapore Special Economy Zone and expand cooperation in aviation.

[16] He launched the think tank Centre for Research, Dialogue & Cooperation (CRDC), a part of the Ministry of Education, on 12 April 2016.

[18] Seyoum served as the Chairman for ten years until 2011 and was a member of the management board of Ethiopian Airlines.

He co-chaired two international track 1.5 dialogues featuring participants from the U.S, China, and various African countries in Johannesburg and Addis Ababa.